Limbaugh has often verbally doted on his wife in what appeared to be a strong union.
Limbaugh says he and Marta will strive to reach an amicable resolution to their marriage.
The couple were married in 1994 and their 10th anniversary just passed on May 27. They moved into a $30 million dollar mansion in 1996 located in West Palm Beach, Florida.
In a statement, Limbaugh noted that the couple was now separated.
As to the reasons for the divorce, none were announced but the famed conservative talk-show host has been under pressure the last couple of years due to personal problems.
On October 10, 2003 the host revealed to his audience that he was addicted to prescription pain killers.
Prior to that, on October 3 of the same year, Limbaugh resigned from an ESPN football commentator job after he made some comments which were taken as racially insensitive.
Both Rush and Marta Limbaugh have been married three times.